

   BBlloooodd PPrreessssuurree iinn RRaabbbbiittss

   AArrgguummeennttss::

   BPchange: change in blood pressure relative to the start of
             the experiment

       Dose: dose of Phenylbiguanide in micrograms

        Run: label of run (`"C1"' to `"C5"', then `"M1"' to
             `"M5"')

   Treatment: placebo or the 5-HT_3 antagonist MDL 72222

     Animal: label of animal used (`"R1"' to `"R5"')

   SSUUMMMMAARRYY::

        Five rabbits were studied on two occasions, after
        treatment with saline (control) and after treatment
        with the 5-HT_3 antagonist MDL 72222.  After each
        treatment ascending doses of phenylbiguanide were
        injected intravenously at 10 minute intervals and the
        responses of mean blood pressure measured.  The goal
        was to test whether the cardiogenic chemoreflex
        elicited by phenylbiguanide depends on the activation
        of 5-HT_3 receptors.

   DDAATTAA DDEESSCCRRIIPPTTIIOONN::

        This data frame contains 60 rows and the following
        variables:

   SSOOUURRCCEE::

        J. Ludbrook (1994) Repeated measurements and multiple
        comparisons in cardiovascular research.  Cardiovascular
        Research 28, 303-311.  [The numerical data are not in
        the paper but were supplied by Professor Ludbrook]

